In a large bowl, combine ground beef with Worcestershire sauce, garlic powder, onion powder, salt, and pepper. Mix gently until just combined.
Divide meat mixture into 12 equal portions (about 1.3 oz each). Form into patties slightly larger than your buns. Press a small indent in the center of each patty.
Heat olive oil in a large skillet over medium heat until shimmering.
Place patties in the skillet without overcrowding. Cook for 2-3 minutes until a golden crust forms.
Flip patties and cook for another 1-2 minutes for medium doneness.
Place a quarter slice of cheddar on each patty. Cover the skillet for about 30 seconds until cheese melts.
Meanwhile, mix mayonnaise, ketchup, Dijon mustard, and sweet relish in a small bowl for the slider sauce.
Brush melted butter on the cut sides of slider buns and toast in a separate skillet until golden brown.
Spread slider sauce on both halves of the buns.
Place cheese-topped patties on bottom buns and add optional toppings like pickles, lettuce, tomato, or onion.
Top with remaining bun halves and serve immediately while warm.
Notes
For juicier sliders, avoid overworking the meat mixture when forming patties.
Make the patties slightly larger than your buns as they will shrink during cooking.
For a party presentation, arrange assembled sliders on a large platter with extra pickles on the side.
Nutrition facts are estimates and may vary based on ingredients used, portion sizes, and preparation methods.
Nutrition
Serving Size:2 sliders
Calories:385
Sugar:5
Sodium:620
Fat:24
Saturated Fat:10
Unsaturated Fat:12
Carbohydrates:25
Fiber:1
Protein:19
Cholesterol:75
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